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Clinics in Manchester, Harley Street - London
The University of Manchester - Hair follicle biology: influencing hair growth and the role of epithelial stem cell populations

The research group at Manchester University, headed by Professor Ralf Paus, investigates the biology and pathology of the hair follicle as a microcosmic miniorgan in which many of the fundamental problems of biology can be studied in an exemplary fashion. Current research includes investigations into the neuroendocrine properties of the human hair follicle, their impact on mitochondrial function and hair follicle immune status, and the use of adult stem cells populations associated with human skin appendages for regenerative medicine purposes.

Do ABC transporters protect human hair follicles and their epithelial progenitor populations from xenobiotic insult?

IS Haslam, H Faruqi, C El Chami, A Shahmalak, R Paus

ABC transporters are widely understood to act as a pharmacological barrier to the movement of toxins and drugs. Certain members of this superfamily (i.e. ABCB1 and ABCG2) are also expressed in certain stem cell populations, conferring the side-population (SP) phenotype by excluding the nucleic acid marker Hoechst 33342. Within the human hair follicle, little is known about the expression or functions of these transporters and although it is well established that the hair follicle contains an epithelial stem cell population, the presence of ABC proteins is unknown. Within the hair follicle, proliferative progenitor cells in the hair matrix are highly susceptible to cytotoxic damage during chemotherapy treatment. As such, the expression of ABC transporters would be biological beneficial in protecting these vital hair follicle cell populations. This study therefore aimed to assess the expression and localisation of several ABC transporters within the human hair follicle and provide preliminary evidence as to their functional significance.

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Exploring the localisation of murine epithelial hair follicle stem cell markers in the human hair follicle: Sox9 and Lhx2

Authors and affiliations

Talveen Purba1, Iain Haslam1, Asim Shahmalak2, Ralf Paus1,3

The Dermatology Centre, Salford Royal NHS Foundation Trust and Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom

Crown Clinic, Thorley House, Bailey Ln, Manchester

Department of Dermatology, University of Münster, Münster, Germany

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Learning your ABCs: xenobiotic transporter expression in human hair follicles

I. S. Haslam1, A. Shahmalak2, R. Paus1, 3

1. Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom.

2. Crown Cosma Clinic, Manchester, United Kingdom.

3. Department of Dermatology, University of Luebeck, Luebeck, Germany.

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